[The effect of aminazine therapy on the functional state of the brain in children with behavioral disorders]

The study deals with the influence of therapy with chlorpromazine on EEG in children aged 9 to 15 with psychopath-like affective-excitable behavior of residual-organic origin (21 patients, and with pathologic personality development of affective-excitable type (15 patients). Baseline indices of the brain electric activity were compared with those during chlorpromazine treatment. Histographic analysis was applied to EEG. The rate of extinction of various components of orienting response to sound (activation response, vertex-potential, galvanic skin response) were also recorded, as was the reproduction of the rhythm of light flashed at different rates. The results pointed to the increase in pathological signs in the patients' EEG during the prolonged chlorpromazine course that suggested its more careful use in children with psychopath-like affective-excitable behavior.