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Predictive factor for first wheezing episode.
Selda Hançerli-Törün1, Deniz Özçeker, Metin Uysalol
1Division of Pediatric Infectious Diseases, Department of Microbiology and Clinical Microbiology, Istanbul University, Istanbul Faculty of Medicine İstanbul, Turkey. seldahancerli@hotmail.com.
The Turkish Journal of Pediatrics
|May 18, 2016
Summary
Infants hospitalized for virus-induced wheezing were studied. A family history of atopy correlated with earlier onset, but neither atopy nor viral cause predicted disease severity.
Area of Science:
- Pediatrics
- Allergy and Immunology
- Infectious Diseases
Background:
- Virus-induced wheezing is a common respiratory issue in infants.
- Identifying risk factors for severity is crucial for management.
Purpose of the Study:
- To evaluate risk factors in infants hospitalized with moderate to severe virus-induced wheezing.
- To determine the influence of atopy and viral etiology on disease severity.
Main Methods:
- Infants hospitalized with virus-induced wheezing were enrolled.
- Nasopharyngeal swabs identified respiratory viruses.
- Total IgE levels and skin prick tests assessed atopy.
- Clinical severity was evaluated.
Main Results:
- Respiratory Syncytial Virus (33.6%) and Influenza virus (16.3%) were the most common pathogens.
- Children with a positive family history of atopy experienced their first episode earlier (9.0 months) than those without (14.2 months) (p=0.007).
- Neither personal atopy nor viral etiology significantly impacted clinical severity.
Conclusions:
- A positive family history of atopy is associated with earlier onset of virus-induced wheezing in infants.
- Personal atopy does not appear to be a significant predictor of the severity of the first virus-induced wheezy episode.
- Further research may explore other contributing factors to disease severity.
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