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Published on: August 7, 2017
Predictive factor for first wheezing episode
Selda Hançerli-Törün1, Deniz Özçeker, Metin Uysalol
1Division of Pediatric Infectious Diseases, Department of Microbiology and Clinical Microbiology, Istanbul University, Istanbul Faculty of Medicine İstanbul, Turkey. seldahancerli@hotmail.com.
Insights
Infants hospitalized for virus-induced wheezing were studied. A family history of atopy correlated with earlier onset, but neither atopy nor viral cause predicted disease severity.
Area of Science:
- Pediatrics
- Allergy and Immunology
- Infectious Diseases
Background:
- Virus-induced wheezing is a common respiratory issue in infants.
- Identifying risk factors for severity is crucial for management.
Purpose of the Study:
- To evaluate risk factors in infants hospitalized with moderate to severe virus-induced wheezing.
- To determine the influence of atopy and viral etiology on disease severity.
Main Methods:
- Infants hospitalized with virus-induced wheezing were enrolled.
- Nasopharyngeal swabs identified respiratory viruses.
- Total IgE levels and skin prick tests assessed atopy.
- Clinical severity was evaluated.
Main Results:
- Respiratory Syncytial Virus (33.6%) and Influenza virus (16.3%) were the most common pathogens.
- Children with a positive family history of atopy experienced their first episode earlier (9.0 months) than those without (14.2 months) (p=0.007).
- Neither personal atopy nor viral etiology significantly impacted clinical severity.
Conclusions:
- A positive family history of atopy is associated with earlier onset of virus-induced wheezing in infants.
- Personal atopy does not appear to be a significant predictor of the severity of the first virus-induced wheezy episode.
- Further research may explore other contributing factors to disease severity.
Abstract:
The aim of study was to evaluate various risk in patients who were hospitalized with moderate to severe virus-induced wheezing. Infants hospitalized with virus-induced wheezing were enrolled in the study. Respiratory viruses were detected in nasopharyngeal swab and total IgE levels and skin prick tests were performed in all patients. The mean age of the patients was 11.2±9 months. The most common detected viral agents were Respiratory Syncytial Virus, (33.6%), Influenza virus (16.3.%). Children with positive family history of atopy had their first virus-induced wheezing at an earlier age (9.0 ±7.8 months) than the others (14.2±10.8 months), (p=0.007). Atopy and viral etiology did not significantly influence clinical severity of the disease. Although children with positive parental history of atopy experience first virus-induced wheezing at an earlier age, personal atopy was not found as a risk factor for predicting the severity of the first virus-induced wheezy episode.
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