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Updated: Mar 21, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Return to Play After Exertional Rhabdomyolysis
Kevin Schleich1, Tyler Slayman1, Douglas West1
1The University of Iowa, Iowa City.
This study presents a 4-phase progressive program for athletes recovering from exertional rhabdomyolysis, ensuring a safe return to sport without symptom recurrence. The program offers a structured approach for athletic trainers and sports medicine providers.
Area of Science:
- Sports Medicine
- Exercise Physiology
- Clinical Research
Background:
- A significant cluster of exertional rhabdomyolysis cases occurred in collegiate football athletes in 2011.
- Lack of established medical literature guided the development of safe return-to-play protocols.
Purpose of the Study:
- To establish a structured, 4-phase progressive program for athletes returning to sport post-exertional rhabdomyolysis.
- To prevent symptom recurrence and ensure athlete safety during the return-to-play process.
Main Methods:
- Development of a progressive 4-phase program.
- Incorporation of existing recommendations and guidelines.
- Inclusion of continuous clinical and laboratory monitoring.
Main Results:
- The program facilitated a safe and successful return to sport for affected athletes.
- No recurrences of exertional rhabdomyolysis symptoms were reported during the program's implementation.
Conclusions:
- The 4-phase program serves as a safe and effective foundation for athlete return-to-play.
- The program is adaptable to individual athlete circumstances and responses to activity.
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