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Related Experiment Videos

Decrease of serum sex hormone-binding globulin as a marker of androgen sensitivity. Correlation with clinical

M Ciaccio1, M Rivarola, A Belgorosky

  • 1Centro de Investigaciones Endocrinológicas, Hospital de Niños, Buenos Aires, Argentina.

Acta Endocrinologica
|April 1, 1989
PubMed
Summary

The androgen sensitivity test is useful for evaluating hormone response in prepubertal children over 3 months old with ambiguous genitalia. Clinical response correlates well with the test in older infants, aiding diagnosis.

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Area of Science:

  • Pediatric Endocrinology
  • Reproductive Medicine
  • Biochemistry

Background:

  • Assessing androgen sensitivity in infants with disorders of sex development is crucial for diagnosis and management.
  • Exogenous testosterone administration is used to evaluate the biochemical and clinical response in these patients.
  • Sex hormone-binding globulin (SHBG) decrease after testosterone is a potential marker for androgen sensitivity.

Purpose of the Study:

  • To evaluate the usefulness of the decrease in serum sex hormone-binding globulin (SHBG) after exogenous testosterone as an androgen sensitivity test.
  • To compare the biochemical response (androgen sensitivity test) with the clinical response in prepubertal patients.
  • To determine the age-dependent utility of the androgen sensitivity test.

Main Methods:

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  • Studied 55 prepubertal patients with ambiguous external genitalia or micropenis.
  • Administered exogenous testosterone and measured serum SHBG levels (biochemical response).
  • Assessed clinical signs of androgen stimulation of external genitalia.
  • Divided patients into two age groups: younger than 3 months (Group I) and older than 3 months (Group II).

Main Results:

  • A correlation between the androgen sensitivity test and clinical response was observed in 54% of Group I patients (n=11).
  • A strong correlation was found in 91% of Group II patients (n=44).
  • Two patients with a negative test and micropenis had pituitary deficiency, indicating a potential cause for lack of correlation.

Conclusions:

  • The androgen sensitivity test and clinical response to androgens are useful in prepubertal patients older than 3 months with disorders of sex differentiation.
  • The androgen sensitivity test is a reliable indicator of androgen sensitivity in older infants.
  • Clinical response is particularly useful in early life when a positive response is observed.