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Updated: Mar 21, 2026

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(18)F-FDG PET/CT Findings in Acute Epstein-Barr Virus Infection Mimicking Malignant Lymphoma

Mathilde Ørbæk1, Jesper Graff2, Elena Markova3

  • 1Department of Infectious Diseases, Copenhagen University Hospital Hvidovre, Kettegaards Allé 30, DK-2650 Hvidovre, Denmark. mathilde.jensen@sund.ku.dk.

Diagnostics (Basel, Switzerland)
|May 18, 2016
PubMed

We present a case demonstrating the diagnostic work-up and follow-up of a patient with acute Epstein-Barr virus (EBV) infection in which the clinical picture and imaging on (18)F-FDG PET/CT mimicked malignant lymphoma. Follow-up (18)F-FDG PET/CT scan in the patient performed 7 weeks after the abnormal scan revealed complete resolution of the metabolically active disease in the neck, axillas, lung hili, and spleen. This case highlights inflammation as one of the most well established false positives when interpreting (18)F-FDG PET/CT scans.

Keywords:
18F-FDG PET/CTEpstein-Barr virusinfectious mononucleosislymphadenopathymalignant lymphoma

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