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Enhanced Lineage-Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony
Maricela Maldonado1, Gerardo Ico1, Karen Low1
1Department of Bioengineering, University of California-Riverside, Materials Science & Engineering Building 331, 900 University Avenue, Riverside, CA, 92521, USA.
Advanced Healthcare Materials
|May 18, 2016
Abstract:
Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation. On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.
Keywords:
differentiationelectrospun scaffoldsinduced pluripotent stem cellsmechanical stem cell niche
