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Updated: Mar 21, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
Copy number variations in Hanwoo and Yanbian cattle genomes using the massively parallel sequencing data
Jung-Woo Choi1, Won-Hyong Chung2, Kyu-Sang Lim2
1Division of Animal Genomics & Bioinformatics, National Institute of Animal Science, RDA, Jeonju 565-851, Republic of Korea; College of Animal Life Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Genome-wide analysis reveals Hanwoo and Yanbian cattle are genetically close, with 901 copy number variation regions identified. These variations offer insights into economically important cattle traits.
Area of Science:
- Genomics
- Comparative Genomics
- Animal Genetics
Background:
- Hanwoo (indigenous Korean cattle) and Yanbian cattle share a common ancestor.
- These breeds have undergone distinct selection pressures over recent decades.
- Understanding genetic variations is crucial for cattle breeding and trait development.
Purpose of the Study:
- To compare genome-wide copy number variations (CNVs) between Hanwoo and Yanbian cattle.
- To identify CNV regions (CNVRs) and assess their potential functional roles.
- To provide genomic resources for understanding cattle trait associations.
Main Methods:
- Whole-genome sequencing data from Hanwoo and Yanbian cattle were analyzed.
- Approximately 3.12 billion and 3.07 billion sequence reads were utilized, respectively.
- Identification of 901 putative CNV regions (CNVRs) across the genome.
Main Results:
- A total of 901 CNVRs were identified, covering 5,513,340bp.
- 53.2% of CNVRs represented gains and 46.8% represented losses in Hanwoo cattle.
- 278 genic-CNVRs were found, with significant enrichment in GO terms related to development, reproduction, and stimulus response.
Conclusions:
- The high genetic similarity between Hanwoo and Yanbian cattle is indicated by the number of identified CNVRs.
- Identified genic-CNVRs are potential candidates for economically important traits in cattle.
- This study provides valuable genomic data for future research on cattle trait genetics.
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