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Updated: Mar 21, 2026

Measurement of Chitinase Activity in Biological Samples
Published on: August 22, 2019
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Michelino Di Rosa1, Lucia Malaguarnera
1Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy.
Abstract:
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18 chitinases, expressed in innate immune cells and involved in endothelial dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a variety of inflammatory diseases of infectious and non-infectious aetiology, it is recognised as a non-invasive prognostic biomarker for inflammation. A variety of studies revealing the increase in CHI3L1 levels in obesity, insulin resistance and in pathological conditions, such as atherosclerosis, coronary artery disease, acute ischaemic stroke, nephropathy, diabetic retinopathy and osteolytic processes, have suggested that CHI3L1 may also play a critical role in the evolution and complication of diabetes mellitus (DM). In this review we highlight the impact of CHI3L1 expression in DM and its contribution to the complication of this disease.
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