Related Experiment Video
Updated: Mar 21, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
[Chlamydia trachomatis infection in mother and child; the importance of a complete history and efficient
Jolanda C Naafs1, Mirjam Y Kleinhout
1St. Antonius Ziekenhuis, afd. Kindergeneeskunde, Nieuwegein.
Insights
Chlamydia trachomatis pneumonia is a common cause of persistent cough in infants. Early diagnosis requires considering maternal history and symptoms like conjunctivitis for effective treatment.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatal Medicine
Background:
- Infants presenting with persistent cough pose diagnostic challenges for general practitioners and pediatricians.
- Maternal health history and condition are crucial in diagnosing infant respiratory illnesses.
Observation:
- A 4-week-old infant with persistent cough and dyspnea was hospitalized.
- The infant's mother presented with abdominal pain and elevated inflammatory markers, with a history of ectopic pregnancy.
- The infant developed purulent conjunctivitis, and initial diagnoses included viral bronchiolitis or whooping cough.
Findings:
- Chlamydia trachomatis (C. trachomatis) polymerase chain reaction (PCR) testing was positive in both the infant and mother.
- C. trachomatis pneumonia was confirmed as the cause of the infant's severe respiratory symptoms.
Implications:
- Chlamydia trachomatis pneumonia is an important, often overlooked, cause of infant cough.
- Comprehensive patient history and inter-specialist communication are vital for accurate diagnosis and management.
- This case highlights the need to consider atypical pathogens in infant respiratory infections.
Abstract:
General practitioners and paediatricians are frequently confronted with coughing infants. The age of the infant, the history of both mother and child, as well as the current maternal condition may provide important diagnostic information. A 4-week-old male infant was referred to the paediatrician with a persistent cough. He was admitted to hospital with dyspnoea and need for supplemental oxygen. Meanwhile, his mother was admitted with unexplained abdominal pain and elevated laboratory inflammation markers. Her history revealed an ectopic pregnancy. The infant's condition, for which the initial differential diagnosis was viral bronchiolitis or whooping cough, deteriorated. His medical history revealed a purulent conjunctivitis. Chlamydia trachomatis PCR turned out to be positive in both mother and child. C. trachomatis pneumonia is a common, yet often overlooked cause of cough in infants. This clinical lesson emphasises the importance of a complete history and efficient communication between medical specialists.
Related Concept Videos
Sexually Transmitted Infections
Bacterial Phylum Chlamydiae
Development of the Oral Microbiota
Cytomegalovirus Disease
Meiosis vs. Mitosis
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Urinary Tract Infection II: Pathophysiology

