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Circulating long non-coding RNAs in cancer: current status and future perspectives.
Peng Qi1,2,3, Xiao-Yan Zhou1,2,3, Xiang Du4,5,6,7
1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Molecular Cancer
|May 19, 2016
Summary
Circulating long non-coding RNAs (lncRNAs) show promise as cancer biomarkers for diagnosis and prognosis. Standardized detection protocols are crucial for validating their clinical significance.
Area of Science:
- Molecular Biology
- Oncology
- Biomarker Discovery
Background:
- Long non-coding RNAs (lncRNAs) are RNA transcripts exceeding 200 nucleotides with minimal protein-coding capacity.
- Circulating lncRNAs are emerging as potential biomarkers for cancer diagnosis, prognosis, and treatment monitoring.
- Current research highlights the feasibility of using lncRNAs in clinical oncology.
Purpose of the Study:
- To review the clinical value of circulating lncRNAs as cancer biomarkers.
- To discuss challenges and potential solutions for implementing lncRNAs in clinical settings.
- To emphasize the need for standardized protocols in lncRNA detection.
Main Methods:
- Literature review of studies on circulating lncRNAs in cancer.
- Analysis of factors affecting lncRNA measurement and detection.
- Discussion of current challenges in sample handling, normalization, and standardization.
Main Results:
- Circulating lncRNAs demonstrate potential as diagnostic and prognostic markers across various malignancies.
- Independent studies confirm the feasibility of using lncRNAs for cancer assessment.
- Significant challenges hinder widespread clinical adoption, including sample variability and lack of standardized protocols.
Conclusions:
- Circulating lncRNAs hold great potential for improving cancer management and disease outcome.
- Further research is needed to fully characterize factors influencing lncRNA measurements.
- Establishing global consensus on standardized procedures is essential for validating the clinical significance of circulating lncRNAs.
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