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Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution

Richard N McLaughlin1, Jacob T Gable2, Cristina J Wittkopp3

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA hsmalik@fhcrc.org.

Molecular Biology and Evolution
|May 19, 2016
PubMed
Summary

APOBEC3A proteins conserve their LINE-1 restriction ability despite rapid evolution in primates. This factor also gained antiviral functions, suggesting adaptation to new pathogens without compromising genome defense against retroelements.

Keywords:
APOBEC3ALINE-1innate immunitypositive selectionprimates.restriction factorretroelements

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