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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Antiasthma Drugs: β2-Adrenoceptor Agonists

Antiasthma Drugs: β₂-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...

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Updated: Mar 21, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma.

Stephen T Holgate¹, Sally Wenzel², Dirkje S Postma³

¹Clinical and Experimental Sciences, Mail Point 810, Level F, Sir Henry Wellcome Building, Southampton General Hospital, Southampton, SO16 6YD, UK.

Nature Reviews. Disease Primers

|May 19, 2016

Summary

This summary is machine-generated.

Asthma, a common lung inflammatory disease, is rising globally. Understanding its diverse mechanisms and lifelong progression is key to developing personalized prevention and cure strategies.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Area of Science:

Pulmonology and Immunology
Environmental Health
Genetics and Epigenetics

Background:

Asthma is a prevalent, increasing inflammatory lung disease with significant global health and economic impact.
It affects airways of all sizes, involving inflammation and structural remodeling potentially starting before birth.
Disease onset and progression are linked to allergic sensitization and influenced by genetic, environmental, and epigenetic factors throughout life.

Purpose of the Study:

To explore the complex, multifactorial nature of asthma development and progression.
To highlight the role of endotypes, epigenetics, and structural changes in asthma.
To emphasize the potential for personalized, pathway-specific prevention and treatment strategies.

Main Methods:

Review of current understanding of asthma pathophysiology.
Analysis of genetic, environmental, epigenetic, and immunological factors.
Examination of asthma subphenotypes across the lifespan.

Main Results:

Asthma involves diverse endotypes influencing disease characteristics and evolution.
Structural airway changes, innate immunity, and microbiota interactions play crucial roles.
Epigenetic mechanisms interconnect genetic and environmental drivers from prenatal stages.

Conclusions:

Subphenotyping asthma across the lifecourse enables personalized, precise, pathway-specific interventions.
Emerging research suggests the potential for complete asthma prevention and cure.
Further understanding of asthma acquisition and remission factors is needed.