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Published on: February 27, 2021
Synthesis, characterization and bioactivities of N,O-carbonylated chitosan
Hongli Liu1, Xiaoli Liu1, Lin Yue1
1State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi, 214122 Jiangsu, People's Republic of China.
Abstract:
N,O-Carbonylated chitosan derivative (NTCS) was synthesized via oxidation and substitution reaction, respectively. The carboxyethylation of the polysaccharide was identified by Fourier transform infrared (FTIR), (1)H nuclear magnetic resonance (NMR), X-ray diffraction analysis (XRD), Zeta potential measurement and Thermogravimetric analysis (TGA). It is revealed that compared with chitosan (CS), NTCS exhibited an excellent solubility in distilled water, high in vitro bile acid binding capacity, as well as a low viscosity. The in vitro bile acid binding capacity reached 17.21mg/g, which was 4.5-fold higher than that of CS. The results suggest that NTCS may be useful as a potential functional food supplement in food industry or a key ingredient in the pharmaceutical industry. These findings provide important supports for developing new food additive, and expand the scope of application of CS in the food industry.
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