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Related Experiment Videos

Benign postoperative jaundice complicating severe trauma.

S Hartley, A J Scott, M Spence

    The New Zealand Medical Journal
    |August 24, 1977
    PubMed
    Summary

    Severe trauma can cause deep jaundice and adult respiratory distress syndrome (ARDS). This liver condition is linked to respiratory failure rather than circulatory failure, and may worsen with transfusions.

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    Area of Science:

    • Hepatology
    • Critical Care Medicine
    • Pathology

    Background:

    • Severe trauma can lead to complex medical conditions.
    • Postoperative jaundice is a known, though distinct, clinical entity.
    • Hypoxia, from respiratory or circulatory failure, can impact organ function.

    Purpose of the Study:

    • To describe a specific syndrome of deep jaundice following severe trauma.
    • To investigate the association between this jaundice and the type of hypoxia.
    • To identify factors that may accentuate this condition.

    Main Methods:

    • Case series describing five patients with severe trauma.
    • Clinical observation of jaundice, acute renal failure, and adult respiratory distress syndrome (ARDS).
    • Autopsy examination of liver pathology.

    Main Results:

    • All five patients developed deep jaundice and ARDS.
    • Only two patients exhibited acute renal failure.
    • Autopsies revealed enlarged livers with centrilobular congestion and cholestasis.
    • The syndrome was more strongly associated with hypoxic hypoxia (respiratory failure) than stagnant hypoxia (circulatory failure).
    • Blood transfusions and disseminated intravascular coagulation (DIC) appeared to accentuate the condition.

    Conclusions:

    • Deep jaundice following severe trauma is linked to ARDS and primarily associated with respiratory failure.
    • The liver pathology suggests a mechanism related to hypoxic hypoxia.
    • Transfusions and DIC may exacerbate this traumatic jaundice syndrome.

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