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Characterization of the gene encoding a fibrinogen-related protein expressed in Crassostrea gigas hemocytes

M A Skazina1, A M Gorbushin2

  • 1Saint-Petersburg State University, Russia.

Fish & Shellfish Immunology
|May 19, 2016
PubMed

Four exons of the CgFrep1 gene (3333 bp long) encode a putative fibrinogen-related protein (324 aa) bearing a single C-terminal FBG domain. Transcripts of the gene obtained from hemocytes of different Pacific oysters show prominent individual variation based on SNP and indels of tandem repeats resulted in polymorphism of N-terminus of the putative CgFrep1 polypeptide. The polypeptide chain bears N-terminal coiled-coil region potentially acting as inter-subunit interface in the protein oligomerization. It is suggested that CgFrep1 gene encodes the oligomeric lectin composed of at least two subunits.

Keywords:
HemocytesImmune receptor moleculesInnate immunityMollusca

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