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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Thermal Insulation in Masonry Walls01:22

Thermal Insulation in Masonry Walls

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In hot, dry climates, the thermal mass of masonry walls can be beneficial, absorbing heat during the day and releasing it at night, thereby stabilizing indoor temperatures. However, in most other climates, additional insulation is necessary to enhance thermal resistance.
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Related Experiment Video

Updated: Mar 21, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

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No insulating effect of obesity.

Alexander W Fischer1, Robert I Csikasz2, Gabriella von Essen2

  • 1Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden; and Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

American Journal of Physiology. Endocrinology and Metabolism
|May 19, 2016
PubMed
Summary

Obesity does not increase thermal insulation in mice, contrary to expectations. This finding suggests that obesity itself does not worsen its own development by reducing heat loss.

Keywords:
insulationob/obobesity

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Area of Science:

  • Physiology
  • Metabolic Research
  • Animal Models

Background:

  • Obesity development may be linked to insulation, which affects energy expenditure for thermoregulation.
  • Mice in laboratory settings experience chronic cold stress (around 20°C), making insulation a relevant factor.

Purpose of the Study:

  • To investigate whether obesity enhances thermal insulation in mice.
  • To determine if increased insulation due to obesity aggravates its development.

Main Methods:

  • Utilized Scholander plots to measure thermal conductance (insulation) by plotting energy expenditure against ambient temperature.
  • Verified the methodology by comparing insulation in shaved versus non-shaved mice.
  • Examined various obesity models, including diet-induced obesity, ob/ob mice, and obesity-prone vs. obesity-resistant strains.

Main Results:

  • Thermal insulation was not affected by acclimation temperature or any type/degree of obesity when analyzed at the whole mouse or per lean weight level.
  • Calculations based on total body weight erroneously suggested increased insulation in obese mice.
  • Shaved mice exhibited half the insulation of non-shaved mice, validating the measurement technique.

Conclusions:

  • Obesity, regardless of its cause or extent, does not increase thermal insulation in mice.
  • Contrary to hypothesis, obesity does not aggravate its own development by enhancing insulation.
  • Further research is needed to understand the role of adipose tissue in human insulation and associated metabolic effects.