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Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
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Macrophage migration inhibitory factor, a role in COPD.

Gunnar R Husebø1, Per S Bakke2, Rune Grønseth3

  • 1Department of Thoracic Medicine, Haukeland University Hospital, Bergen Norway; Department of Clinical Science, University of Bergen, Bergen, Norway; gunnar.husebo@med.uib.no.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|May 19, 2016
PubMed
Summary

Serum levels of Macrophage Migration Inhibitor Factor (MIF) are significantly elevated in patients with chronic obstructive pulmonary disease (COPD) and increase further during acute exacerbations (AECOPD). This highlights MIF

Keywords:
COPDCOPD exacerbationbiomarkerglucocorticoid resistancemacrophage migration inhibitory factor

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Area of Science:

  • Pulmonology
  • Immunology
  • Biochemistry

Background:

  • Macrophage Migration Inhibitor Factor (MIF) is a cytokine implicated in inflammatory conditions.
  • The specific role of MIF in lung inflammation and Chronic Obstructive Pulmonary Disease (COPD) requires further elucidation.

Purpose of the Study:

  • To investigate serum MIF levels in patients with stable COPD compared to healthy controls.
  • To assess changes in MIF levels during acute exacerbations of COPD (AECOPD).

Main Methods:

  • Serum MIF levels were measured in 433 COPD patients and 325 controls.
  • MIF levels were re-evaluated in 149 COPD patients during AECOPD.
  • Linear regression models adjusted for covariates were employed.

Main Results:

  • COPD patients exhibited significantly higher serum MIF levels than controls (20.1 vs 14.9 ng/ml).
  • MIF levels were significantly elevated during AECOPD compared to stable COPD (23.2 vs 19.3 ng/ml).
  • MIF levels showed associations with sex, body composition, and Charlson Comorbidity Score.

Conclusions:

  • Serum MIF is significantly elevated in COPD patients.
  • MIF levels increase further during AECOPD, suggesting a role in disease exacerbation.
  • These findings indicate MIF as a potential biomarker for COPD activity and exacerbations.