Related Experiment Video

Updated: Mar 21, 2026

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

2.8K

Virus and Host Testing to Manage Chronic Hepatitis B

Grace Lai-Hung Wong1, Vincent Wai-Sun Wong1, Henry Lik-Yuen Chan1

  • 1Department of Medicine and Therapeutics Institute of Digestive Disease State Key Laboratory of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|May 19, 2016
PubMed

Insights

Advances in hepatitis B virus (HBV) testing, including HBV DNA and hepatitis B surface antigen quantification, improve understanding and management of chronic HBV infection. Genomic studies offer potential for novel diagnostic tools in the future.

Area of Science:

  • Hepatology and Virology
  • Diagnostic Technologies
  • Infectious Disease Management

Background:

  • Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and hepatocellular carcinoma globally.
  • Significant advancements in HBV testing have occurred over the last 50 years.
  • Understanding HBV virology and natural history has been enhanced by sensitive HBV DNA assays.

Purpose of the Study:

  • To review recent progress in HBV testing.
  • To highlight the application of advanced HBV tests in managing chronic hepatitis B.
  • To discuss the role of HBV DNA and hepatitis B surface antigen quantification.

Main Methods:

  • Review of traditional serologic tests.
  • Analysis of sensitive HBV DNA assays.
  • Evaluation of hepatitis B surface antigen quantification.
  • Exploration of recent genomic studies on host-virus interactions.

Main Results:

  • HBV DNA assays provide a comprehensive understanding of HBV virology and natural history.
  • Hepatitis B surface antigen quantification correlates with covalently closed circular DNA activity in the liver.
  • Genomic research is uncovering host-virus relationships, potentially leading to new diagnostic methods.

Conclusions:

  • Modern HBV testing, including HBV DNA and hepatitis B surface antigen quantification, is crucial for disease staging and guiding antiviral therapy.
  • The interplay between host genetics and HBV is increasingly understood, paving the way for future diagnostic innovations.
  • This review emphasizes the evolving landscape of HBV diagnostics and their impact on patient management.

Keywords:
cirrhosishepatitis B e antigenshepatitis B surface antigenshepatocellular carcinomapeginterferon alfa

More Related Videos

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

14.1K
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

12.3K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
7
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
249
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.2K