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Ebolavirus Database: Gene and Protein Information Resource for Ebolaviruses
Rayapadi G Swetha1, Sudha Ramaiah1, Anand Anbarasu1
1Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.
Advances in Bioinformatics
|May 19, 2016
Summary
Ebola Virus Disease (EVD) research is advanced by the new Ebolavirus Database (EDB). This resource aids in understanding ebolavirus protein functions and virulence factors for better EVD diagnostics and treatment.
Area of Science:
- Virology
- Genomics
- Bioinformatics
Background:
- Ebola Virus Disease (EVD) is a severe hemorrhagic fever with poorly understood viral protein functions and virulence factors.
- Existing research on EVD lacks comprehensive genomic and proteomic analysis tools.
Purpose of the Study:
- To develop an integrated resource, the Ebolavirus Database (EDB), for comparative genomic and proteomic analyses of ebolaviruses.
- To facilitate the identification of essential genes, protein functions, and virulence factors of ebolaviruses.
Main Methods:
- Development of the Ebolavirus Database (EDB).
- Integration of various bioinformatics tools for genomic and proteomic analysis.
- Comparative genomic analysis of ebolaviruses.
Main Results:
- The EDB provides researchers with tools to locate important regions in ebolavirus genomes and proteomes.
- Genomic analyses offer insights into essential and core functional genes.
- The database serves as a centralized hub for ebolavirus research.
Conclusions:
- The Ebolavirus Database (EDB) is a valuable integrated resource for researchers studying ebolaviruses.
- EDB will aid clinicians, microbiologists, healthcare workers, and bioscience researchers in understanding EVD pathogenesis and developing interventions.
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