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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Luca Genovese1, Andrea Brendolan1

  • 1Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

Stem Cells International
|May 19, 2016
PubMed

Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.

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