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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Direct acting antiviral therapy is curative for chronic hepatitis C/autoimmune hepatitis overlap syndrome
Farhad Sahebjam1, Cristina H Hajdu1, Esther Nortey1
1Farhad Sahebjam, Esther Nortey, Samuel H Sigal, Division of Gastroenterology, New York University School of Medicine, New York, NY 10016, United States.
Abstract:
Autoimmune phenomena are common in patients with chronic hepatitis C. Management of chronic hepatitis C/autoimmune hepatitis syndrome has until recently been problematic due to the adverse effects of interferon on autoimmune processes and immunosuppression on viral replication. In this report we describe 3 patients with chronic hepatitis C/autoimmune hepatitis overlap syndrome who responded rapidly to direct acting anti-viral therapy. The resolution of the autoimmune process supports a direct viral role in its pathophysiology.
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