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Related Concept Videos

ATP Synthase: Structure01:18

ATP Synthase: Structure

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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Synthetic Biology02:55

Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
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Amines to Sulfonamides: The Hinsberg Test01:23

Amines to Sulfonamides: The Hinsberg Test

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The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
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tRNA Activation02:26

tRNA Activation

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Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
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Related Experiment Video

Updated: Mar 21, 2026

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

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Antisynthetase syndrome: a case report.

Mehwish Asif Qureshi1, Edward Hoey1, Timothy Fletcher1

  • 11 Registrar General Practice, Westmidlands, UK ; 2 Consutlant Radiologist, 3 Respiratory Physicians, Good Hope Hospital, Birmingham, UK.

Quantitative Imaging in Medicine and Surgery
|May 19, 2016
PubMed
Summary

Antisynthetase syndrome (ASS) diagnosis in a 48-year-old man was confirmed by elevated inflammatory markers, specific antibodies, and characteristic lung imaging. High-resolution CT scans were crucial for identifying mediastinal lymph nodes and lung nodules, aiding diagnosis and management.

Keywords:
Antisynthetase syndrome (ASS)high resolution computed tomography (HRCT)interstitial lund disease (ILD)

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Area of Science:

  • Rheumatology
  • Pulmonology
  • Medical Imaging

Background:

  • Antisynthetase syndrome (ASS) is a rare autoimmune disease characterized by interstitial lung disease, myositis, and mechanic's hands.
  • Early diagnosis and management are crucial for improving patient outcomes.

Observation:

  • A 48-year-old male presented with a one-week history of worsening dyspnea and decreased exercise capacity.
  • Laboratory tests revealed elevated erythrocyte sedimentation rate (ESR), creatine kinase (CK), and positive anti-aminoacyl-tRNA synthetase antibodies.

Findings:

  • High-resolution computed tomography (HRCT) of the chest demonstrated prominent mediastinal lymphadenopathy and scattered pulmonary nodules.
  • The combination of clinical presentation, serological markers, and characteristic radiological findings confirmed the diagnosis of ASS.

Implications:

  • This case highlights the importance of integrating clinical, laboratory, and radiological findings for accurate ASS diagnosis.
  • HRCT imaging plays a pivotal role in identifying key features of ASS, guiding therapeutic strategies, and monitoring disease progression.