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Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors
G Kovacs1, C Welter, L Wilkens
1Institute of Pathology, Hannover Medical School, Federal Republic of Germany.
The American Journal of Pathology
|May 1, 1989
Abstract:
The light and electron microscopic morphology of two renal parenchymal tumors was consistent with the diagnosis of renal oncocytoma. Both tumors had a mosaic chromosome pattern of cells with normal and abnormal karyotypes. No recurrent chromosome aberration and also no rearrangement of chromosome 3p was found. Restriction analysis of the mitochondrial DNA revealed a new autoradiographic band at about 50 basepairs in size occurring exclusively in oncocytomas. The possible use of these findings in the diagnosis of renal oncocytomas is discussed.