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Effect of Silybin on Lipid Profile in Hypercholesterolaemic Rats

Senthil Gobalakrishnan1, Sylvia Santhakumari Asirvatham2, Venkatraman Janarthanam3

  • 1Assistant Professor, Department of Pharmacology, Sri Manakula Vinayagar Medical college , Pondicherry, India .

Journal of Clinical and Diagnostic Research : JCDR
|May 19, 2016
PubMed

Insights

Silybin effectively lowered cholesterol and triglycerides in hypercholesterolemic rats. This natural compound shows promise as a hypolipidemic agent, reducing LDL-C and increasing HDL-C levels.

Area of Science:

  • Pharmacology
  • Biochemistry
  • Cardiovascular Research

Background:

  • Hyperlipidemia is a primary driver of atherosclerosis and related cardiovascular diseases like Coronary Heart Disease (CHD).
  • Existing hypolipidemic drugs necessitate ongoing research for more effective alternatives.

Purpose of the Study:

  • To investigate the hypolipidemic effects of Silybin in a rat model of hypercholesterolemia.
  • To evaluate Silybin's impact on serum and hepatic lipid profiles.

Main Methods:

  • Hypercholesterolemic rats were administered Silybin at doses of 300mg and 600mg for 60 days.
  • Plasma and liver biochemical analyses were performed post-fasting.
  • Data were statistically analyzed using ANNOVA and Duncan's test (p≤0.05).

Main Results:

  • High cholesterol diet significantly elevated serum total cholesterol, triglycerides, LDL-C, and VLDL-C.
  • Silybin treatment dose-dependently reduced serum total cholesterol (24%), triglycerides (21%), and LDL-C (24%).
  • Silybin increased hepatic HDL-C and decreased other hepatic lipid profiles.

Conclusions:

  • Silybin demonstrated significant hypolipidemic effects in hypercholesterolemic rats.
  • Both tested doses of Silybin effectively reduced serum and hepatic cholesterol, triglycerides, VLDL-C, and LDL-C.
  • Silybin also significantly increased HDL-C levels at both doses.
Abstract

Keywords:
Coronary heart diseaseHyperlipidemiaSiliphos

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