Related Experiment Video
Updated: Mar 21, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
An Unusual Case of HCV Negative Cryoglobulinemia Presenting as Symmetrical Peripheral Gangrene
Siba Prasad Dalai1, Lalit Kumar Meher2, Samir Kumar Behera3
1Junior Resident, Department of Medicine, MKCG Medical College , Brahmapur, Odisha, India .
Abstract:
Cryoglobulins are monoclonal or polyclonal immunoglobulins that undergo reversible precipitation at low temperatures. Cryoglobulinemia is associated with HCV infection in more than 90% cases, the remaining 10% being called as Essential Cryoglobulinemia which is generally associated with a severe course and suboptimal response to conventional therapies. As the digital vessels are more prone to colder temperatures, hyperviscosity in those vessels can initiate local thrombosis and may manifest as ischemic ulceration and gangrene. We report here a very unusual case of HCV negative cryoglobulinemic vasculitis presenting as symmetrical peripheral gangrene of fingers and toes.
Related Concept Videos
Cytomegalovirus Disease
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Assessment of the Cardiovascular System III: Palpation
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Endocarditis II: Clinical Features of Infective Endocarditis
Hypersensitivity Reactions: Cytolytic Reactions
Nephrotic Syndrome III : Nursing Management

