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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Pulmonary Aspergillosis: What CT can Offer Before it is too Late!
Akhila Prasad1, Kshitij Agarwal2, Desh Deepak3
1Associate Professor, Department of Radiodiagnosis, PGIMER & Dr Ram Manohar Lohia Hospital , New Delhi, India .
Abstract:
Aspergillus is a large genus of saprophytic fungi which are present everywhere in the environment. However, in persons with underlying weakened immune response this innocent bystander can cause fatal illness if timely diagnosis and management is not done. Chest infection is the most common infection caused by Aspergillus in human beings. Radiological investigations particularly Computed Tomography (CT) provides the easiest, rapid and decision making information where tissue diagnosis and culture may be difficult and time-consuming. This article explores the crucial role of CT and offers a bird's eye view of all the radiological patterns encountered in pulmonary aspergillosis viewed in the context of the immune derangement associated with it.
Insights
Pulmonary aspergillosis, a serious fungal infection caused by Aspergillus, often affects immunocompromised individuals. Computed Tomography (CT) scans are vital for rapid diagnosis and management of this chest infection.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Radiology
Background:
- Aspergillus is a ubiquitous environmental fungus.
- In immunocompromised individuals, Aspergillus can cause life-threatening infections, particularly pulmonary aspergillosis.
- Prompt diagnosis and management are crucial for patient outcomes.
Purpose of the Study:
- To explore the critical role of Computed Tomography (CT) in diagnosing pulmonary aspergillosis.
- To provide an overview of radiological patterns of pulmonary aspergillosis in relation to immune status.
Main Methods:
- Review of radiological findings in pulmonary aspergillosis.
- Correlation of imaging patterns with underlying immune deficiencies.
- Emphasis on the utility of CT in diagnosis.
Main Results:
- Computed Tomography (CT) offers rapid and crucial information for diagnosing pulmonary aspergillosis.
- CT facilitates decision-making, especially when tissue diagnosis or culture is challenging.
- Various radiological patterns are observed, linked to specific immune derangements.
Conclusions:
- CT is an indispensable tool for the timely diagnosis and management of pulmonary aspergillosis.
- Understanding the radiological manifestations of pulmonary aspergillosis in immunocompromised patients is essential.
- Integrated approach of imaging and clinical context improves patient care.
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