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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The immune...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D and autoimmunity.

Y Rosen1, J Daich1, I Soliman1

  • 1a Department of Medicine , Coney Island Hospital , Brooklyn , NY , USA.

Scandinavian Journal of Rheumatology
|May 19, 2016
PubMed
Summary
This summary is machine-generated.

Vitamin D plays a role in modulating autoimmune diseases like multiple sclerosis and rheumatoid arthritis. Further research is needed to understand the exact mechanisms linking vitamin D to these conditions.

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Area of Science:

  • Immunology
  • Endocrinology
  • Nutritional Science

Background:

  • Autoimmune diseases involve the immune system mistakenly attacking the body's own tissues.
  • Vitamin D, a crucial nutrient, is known for its roles in bone health and immune system regulation.

Purpose of the Study:

  • To review and evaluate the current scientific evidence on the role of vitamin D in various autoimmune diseases.
  • To synthesize findings from diverse study types investigating the vitamin D-autoimmunity connection.

Main Methods:

  • A comprehensive literature search was conducted on PubMed.
  • Keywords included 'vitamin D', 'autoimmune disease', and 'autoimmunity'.
  • Studies analyzed encompassed prospective cohorts, cross-sectional, longitudinal, genetic, and experimental models.

Main Results:

  • Evidence suggests vitamin D modulates key autoimmune diseases.
  • Affected conditions include multiple sclerosis (MS), systemic sclerosis (SSc), autoimmune thyroid diseases, rheumatoid arthritis (RA), and primary biliary cirrhosis (PBC).

Conclusions:

  • Current studies indicate vitamin D is a factor in autoimmune disease pathophysiology.
  • The precise mechanisms underlying this association require further elucidation.
  • Additional research is necessary to confirm these findings and their implications.