Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

368
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
368
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

664
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
664
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

439
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
439
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

623
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
623
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Which features best differentiate Sjögren's-related from non-Sjögren's-related dry eye disease?

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry.

Frontiers in immunology·2026
Same author

Corneal nerve alterations in migraine: a systematic review of in vivo confocal microscopy and esthesiometry findings.

Contact lens & anterior eye : the journal of the British Contact Lens Association·2026
Same author

Toxoplasmosis meets the World Health Organization criteria for a neglected tropical disease.

PLoS neglected tropical diseases·2026
Same author

Vogt-Koyanagi-Harada disease frequency around the globe: a systematic review and meta-analysis.

Eye (London, England)·2026
Same author

Drug therapies and immune pathways in ocular manifestations of inflammatory skin diseases.

Expert review of clinical immunology·2026

Related Experiment Video

Updated: Mar 21, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.3K

Pediatric Uveitis: Experience in Colombia.

Marcela Lonngi1,2, María Camila Aguilar1,2, Hernán Andrés Ríos1,2

  • 1a Investigación Fundación Oftalmológica Nacional, Fundación Oftalmológica Nacional , Department of Ophthalmology , Bogotá , Colombia.

Ocular Immunology and Inflammation
|May 19, 2016
PubMed
Summary

Pediatric uveitis in Colombia is primarily caused by infections like toxoplasmosis, often presenting as posterior uveitis with insidious onset and chronic course. This study highlights the need for increased awareness and public health strategies for childhood visual health.

Keywords:
ChildrenColombiaSouth Americadeveloping countriespediatric uveitisuveitis

More Related Videos

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.3K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.7K

Related Experiment Videos

Last Updated: Mar 21, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.3K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.3K
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

17.7K

Area of Science:

  • Ophthalmology
  • Pediatric Medicine
  • Infectious Diseases

Background:

  • Uveitis in children presents unique challenges in diagnosis and management.
  • Understanding the specific epidemiological and clinical characteristics of pediatric uveitis is crucial for effective treatment strategies.
  • Limited data exists on pediatric uveitis in Latin America, particularly in Colombia.

Purpose of the Study:

  • To characterize the clinical presentation of pediatric uveitis.
  • To identify the primary causes and patterns of uveitis in children.
  • To establish baseline data for pediatric uveitis in Colombia.

Main Methods:

  • Retrospective review of clinical records of pediatric patients diagnosed with uveitis.
  • Data collected from two ophthalmology centers in Bogotá, Colombia.
  • Analysis of demographic, clinical, etiological, and visual acuity data.

Main Results:

  • 310 children were included; 51.9% were female, with a mean age of 10.1 years.
  • Posterior uveitis was most common (58.7%), characterized by insidious onset (87.4%) and chronic course (78.1%).
  • Infectious etiology (58.4%) predominated, with toxoplasmosis (76.8%) being the leading cause. Visual acuity was significantly poorer in posterior uveitis compared to anterior and intermediate forms (p<0.05).

Conclusions:

  • This study provides the first comprehensive report on pediatric uveitis in Colombia.
  • Infectious etiologies, particularly toxoplasmosis, are the leading causes of pediatric uveitis in this region.
  • Findings can enhance awareness, guide clinical practice, and inform public health policies for pediatric visual health in developing countries.