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Altered mean platelet volume in patients with polymyositis and its association with disease severity
Abstract:
Polymyositis (PM) is an autoimmune disease characterized by chronic inflammation in skeletal muscle. Mean platelet volume (MPV), a marker in the assessment of systemic inflammation, is easily measured by automatic blood count equipment. However, to our knowledge, there are no data in the literature with respect to MPV levels in PM patients. Therefore, in this study we aimed to investigate MPV levels in patients with PM. This study included 92 newly diagnosed PM patients and 100 healthy individuals. MPV levels were found to be significantly lower compared with healthy controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001). Interestingly, MPV was found to be positively correlated with manual muscle test (MMT) score and negatively correlated with erythrocyte sedimentation rate (ESR) in patients with PM (r=0.239, P=0.022; r=-0.268, P=0.010, respectively). In addition, MPV was significantly lower in active PM patients compared with inactive PM patients (9.9±1.39 vs 10.6±0.92 fL, P=0.010). MPV was independently associated with PM in multivariate regression analyses, when controlling for hemoglobin and ESR (OR=0.312, P=0.031, 95%CI=0.108 to 0.899). The ROC curve analysis for MPV in estimating PM patients resulted in an area under the curve of 0.800, with sensitivity of 75.0% and specificity of 67.4%. Our results suggest that MPV is inversely correlated with disease activity in patients with PM. MPV might be a useful tool for rapid assessment of disease severity in PM patients.
Insights
Mean platelet volume (MPV) is lower in polymyositis (PM) patients and inversely correlates with disease activity. This finding suggests MPV may aid in assessing PM severity.
Area of Science:
- Rheumatology
- Immunology
- Hematology
Background:
- Polymyositis (PM) is an autoimmune disease causing skeletal muscle inflammation.
- Mean platelet volume (MPV) is a readily available marker of systemic inflammation.
- Limited data exists on MPV levels in polymyositis patients.
Purpose of the Study:
- To investigate Mean platelet volume (MPV) levels in newly diagnosed polymyositis (PM) patients.
- To explore the relationship between MPV and disease activity markers in PM.
- To assess the potential of MPV as a biomarker for PM severity.
Main Methods:
- Comparative analysis of MPV levels between 92 newly diagnosed PM patients and 100 healthy controls.
- Correlation analysis between MPV, manual muscle test (MMT) scores, and erythrocyte sedimentation rate (ESR).
- Multivariate regression and ROC curve analysis to evaluate MPV's association with PM and disease activity.
Main Results:
- PM patients exhibited significantly lower MPV levels compared to healthy controls (10.3±1.23 vs 11.5±0.74 fL, P<0.001).
- MPV positively correlated with MMT scores (r=0.239, P=0.022) and negatively with ESR (r=-0.268, P=0.010).
- MPV was significantly lower in active PM patients and independently associated with PM (OR=0.312, P=0.031).
Conclusions:
- Mean platelet volume (MPV) is inversely correlated with disease activity in polymyositis (PM).
- MPV may serve as a valuable, rapid tool for assessing polymyositis disease severity.
- Further research could establish MPV's role in routine clinical management of PM.
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