8-Hydroxyquinolines in medicinal chemistry: A structural perspective.

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Drug Discovery

Background:

• 8-Hydroxyquinolines are heterocyclic compounds with moderate metal-binding affinity.
• Their privileged structure has driven significant interest in drug candidate design over the past two decades.
• Synthetic versatility allows for numerous derivatives and multifunctional analogues.

Purpose of the Study:

• To review 8-hydroxyquinolines, 8-hydroxyquinoline-like compounds, and nanoparticle systems.
• To summarize their diverse biological activities.
• To explore their interactions with metal ions and mechanisms of action.

Main Methods:

• Literature review of 8-hydroxyquinoline derivatives and their applications.
• Analysis of biological activities including neuroprotection, anticancer, antibacterial, and antifungal effects.
• Examination of metal ion interactions and proposed mechanisms of action.

Main Results:

• 8-Hydroxyquinolines exhibit a wide range of biological effects on various targets.
• Derivatives demonstrate potential in neuroprotection, cancer therapy, and antimicrobial applications.
• Understanding metal ion interactions is key to their therapeutic mechanisms.

Conclusions:

• 8-Hydroxyquinolines represent a valuable scaffold for developing novel therapeutic agents.
• Their metal-binding properties are central to their diverse pharmacological activities.
• Further research into 8-hydroxyquinoline-based nanoparticles may offer new delivery systems.