Related Experiment Video

Updated: Mar 21, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K

High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with

Rafael San-Juan, Esther Viedma, Fernando Chaves

    Emerging Infectious Diseases
    |May 19, 2016
    PubMed

    Insights

    High minimum inhibitory concentrations (MICs) for vancomycin and daptomycin predict complications in methicillin-sensitive Staphylococcus aureus (MSSA) catheter-related bloodstream infections (CRBSI). This finding aids in identifying high-risk patients for better management.

    Area of Science:

    • Infectious Diseases
    • Clinical Microbiology
    • Pharmacology

    Background:

    • Catheter-related bloodstream infections (CRBSI) are a significant concern, particularly those caused by Staphylococcus aureus.
    • Optimized clinical management is crucial for treating MSSA CRBSI.
    • Understanding the prognostic role of antimicrobial minimum inhibitory concentrations (MICs) is essential for predicting patient outcomes.

    Purpose of the Study:

    • To investigate the prognostic significance of high MICs for antistaphylococcal agents in patients with MSSA CRBSI.
    • To determine if elevated MICs for vancomycin, daptomycin, oxacillin, and linezolid are associated with the development of complicated bacteremia.
    • To identify risk factors for complicated MSSA CRBSI.

    Main Methods:

    • Prospective review of 83 MSSA CRBSI episodes across 5 Spanish centers (April 2011-June 2014).
    • Analysis of E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid.
    • Multivariate analysis to assess the relationship between MICs and complicated bacteremia development.

    Main Results:

    • Complicated MSSA CRBSI occurred in 31.3% of patients.
    • Higher MICs for vancomycin (cutoff = 1.5 μg/mL) and daptomycin (cutoff = 0.5 μg/mL) were observed in patients with complicated infections.
    • High vancomycin and daptomycin MICs were independent risk factors for complicated MSSA CRBSI (HR 2.4 for both).

    Conclusions:

    • Patients with MSSA CRBSI caused by strains exhibiting high vancomycin or daptomycin MICs face an increased risk of complications.
    • These findings highlight the importance of monitoring antimicrobial susceptibility for predicting outcomes in MSSA CRBSI.
    • Antimicrobial stewardship programs should consider MIC values for guiding treatment decisions in complex cases.
    Keywords:
    CRBIMICMSSAbacteriacatheter-related bloodstream infectioncomplicated bacteremiadaptomycinmethicillin-sensitive Staphylococcus aureusseptic thrombophlebitisvancomycin

    More Related Videos

    In Vivo Mouse Model of Spinal Implant Infection08:03

    In Vivo Mouse Model of Spinal Implant Infection

    Published on: June 23, 2020

    2.9K
    Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria14:04

    Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

    Published on: May 8, 2013

    25.3K

    Related Concept Videos

    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
    7
    Mechanism of Antibiotic Resistance in MRSA01:25

    Mechanism of Antibiotic Resistance in MRSA

    Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
    37
    Estimation of k and VD of Aminoglycosides01:20

    Estimation of k and VD of Aminoglycosides

    Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
    296
    Staphylococcal Skin Infections01:29

    Staphylococcal Skin Infections

    Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
    16
    Combined Effects of Drugs: Synergism01:27

    Combined Effects of Drugs: Synergism

    Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
    Such synergistic combinations...
    7.2K
    Inhibitors of Gram-positive Cell Wall Synthesis01:23

    Inhibitors of Gram-positive Cell Wall Synthesis

    Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
    10