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Infectious Disease Risk Associated with Contaminated Propofol Anesthesia, 1989-2014(1)

Andrés Zorrilla-Vaca, Jimmy J Arevalo, Kevin Escandón-Vargas

    Emerging Infectious Diseases
    |May 19, 2016
    PubMed

    Insights

    Propofol, a common anesthetic, has been linked to patient infections from contaminated vials and improper handling. Despite preventive measures, outbreaks persist, highlighting a need for better strategies to ensure patient safety.

    Area of Science:

    • Anesthesiology
    • Infectious Diseases
    • Public Health

    Background:

    • Propofol is a widely used intravenous anesthetic agent.
    • Iatrogenic infections associated with propofol administration are a concern.
    • Limited data exists on the global epidemiology of propofol-related outbreaks and prevention effectiveness.

    Observation:

    • A review of 58 studies (1989-2014) identified 20 propofol-related outbreaks.
    • These outbreaks affected 144 patients, resulting in 10 deaths.
    • Contributing factors included syringe reuse and open vials left exposed.

    Findings:

    • Antimicrobial additives in propofol emulsions have not fully prevented outbreaks.
    • Significant gaps remain in understanding the efficacy of current preventive measures.
    • Propofol itself can be a source of nosocomial infections.

    Implications:

    • There is a critical need for enhanced infection control protocols for propofol administration.
    • Further research is required to develop and validate effective strategies to prevent propofol-related outbreaks.
    • Improving the safety of propofol use is essential for patient care worldwide.
    Keywords:
    2,6-diisopropylphenolEDTAPropofolanesthesiacontaminationedetate disodiumfospropofolglycerolhospital infectioniatrogenicintravenouslipidemulsionlipophilicnosocomialoutbreakphenolphosphatidesafetysoybean

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