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Updated: Mar 21, 2026
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
Published on: July 29, 2013
Image Quality in Oncologic Chest Computerized Tomography With Iterative Reconstruction: A Phantom Study
Kristin Jensen1, Trond Mogens Aaløkken, Anders Tingberg
1From the *Intervention Centre, Rikshospitalet, Nydalen; †Institute of Physics, University of Oslo; ‡Department of Radiology and Nuclear Medicine, Rikshospitalet, Nydalen, Oslo, Norway; §Department of Medical Radiation Physics, Lund University, Skåne University Hospital, Malmö, Sweden; and ∥Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objective:
The purpose of this study was to validate iterative reconstruction technique in oncologic chest computed tomography (CT).
Methods:
An anthropomorphic thorax phantom with 4 simulated tumors was scanned on a 64-slice CT scanner with 2 different iterative reconstruction techniques: one model based (MBIR) and one hybrid (ASiR). Dose levels of 14.9, 11.1, 6.7, and 0.6 mGy were used, and all images were reconstructed with filtered back projection (FBP) and both iterative reconstruction algorithms. Hounsfield units (HU) and absolute noise were measured in the tumors, lung, heart, diaphragm, and muscle. Contrast-to-noise ratios (CNRs) and signal-to-noise ratios (SNRs) were calculated.
Results:
Model-based iterative reconstruction (MBIR) increased CNRs of the tumors (21.1-192.2) and SNRs in the lung (-49.0-165.6) and heart (3.1-8.5) at all dose levels compared with FBP (CNR, 1.1-23.0; SNR, -7.5-31.6 and 0.2-1.1) and with adaptive statistical iterative reconstruction (CNR, 1.2-33.2; SNR, -7.3-37.7 and 0.2-1.5). At the lowest dose level (0.6 mGy), MBIR reduced the cupping artifact (HU range: 17.0 HU compared with 31.4-32.2). An HU shift in the negative direction was seen with MBIR.
Conclusions:
Quantitative image quality parameters in oncologic chest CT are improved with MBIR compared with FBP and simpler iterative reconstruction algorithms. Artifacts at low doses are reduced. A shift in HU values was shown; thus, absolute HU values should be used with care.
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