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Published on: December 15, 2014
The Use of Breast Magnetic Resonance Imaging Parameters to Identify Possible Signaling Pathways of a Serum Biomarker,
Afak Durur-Karakaya1, Irmak Durur-Subasi, Adem Karaman
1From the *Department of Radiology, Istanbul Medipol University, School of Medicine, Istanbul; Departments of †Radiology, and ‡General Surgery, Atatürk University, School of Medicine; §Department of Pharmaceutical Toxicology, Atatürk University, School of Pharmacy; ∥Department of Radiation Oncology; and ¶Department of Medical Education, Atatürk University, School of Medicine, Erzurum, Turkey.
Objectives:
This study aimed to investigate the relationship between breast magnetic resonance imaging (MRI) parameters; clinical features such as age, tumor diameter, N, T, and TNM stages; and serum human epididymis protein 4 (HE4) levels in patients with breast carcinoma and use this as a means of estimating possible signaling pathways of the biomarker, HE4.
Methods:
Thirty-seven patients with breast cancer were evaluated by breast MRI and serum HE4 levels before therapy. Correlations between parameters including age, tumor diameter T and N, dynamic curve type, enhancement ratio (ER), slope washin (S-WI), time to peak (TTP), slope washout (S-WO), and the serum level of HE4 were investigated statistically. Human epididymis protein 4 levels of early and advanced stage of disease were also compared statistically.
Results:
Breast MRI parameters showed correlation to serum HE4 levels and correlations were statistically significant. Of these MRI parameters, S-WI had higher correlation coefficient than the others. Human epididymis protein 4 levels were not statistically different in early and advanced stage of disease.
Conclusions:
High correlation with MRI parameters related to neoangiogenesis may indicate signaling pathway of HE4.
