Infantile multiple large pyogenic granuloma on burned skin. Case report and review of literature

Area of Science:

• Dermatology
• Pediatrics
• Pathology

Background:

• Pyogenic granuloma (PG) is a common benign vascular lesion, typically solitary and reactive to injury.
• Multiple disseminated PG is rare, especially in infants.
• Exposed sites are common, particularly in children.

Observation:

• This report details an infant presenting with multiple, disseminated pyogenic granulomas.
• The lesions appeared following thermal burns caused by boiling milk.
• A literature review identified 9 cases of disseminated PG, with milk as a common trigger.

Findings:

• Six of the 9 reviewed cases were provoked by hot milk.
• Two cases were linked to hot water burns.
• The underlying mechanism may involve angiogenic activity in milk.

Implications:

• This case highlights a rare presentation of pyogenic granuloma in infants.
• Hot milk burns are a significant potential trigger for disseminated PG.
• Further research into milk's angiogenic properties could elucidate PG development.