Isolated plexiform neurofibroma mimicking a vascular lesion.

Area of Science:

• Oncology
• Dermatology
• Genetics

Background:

• Plexiform neurofibromas are benign tumors arising from peripheral nerve sheaths.
• These tumors are frequently associated with Neurofibromatosis Type 1 (NF1).
• They can cause pain, cosmetic issues, and local invasion.

Observation:

• An adolescent presented with a solitary, giant plexiform neurofibroma on her leg.
• The lesion's clinical presentation mimicked a vascular anomaly.
• Diagnosis was confirmed via surgical biopsy.

Findings:

• Surgical excision of the giant plexiform neurofibroma was successfully performed.
• The patient experienced significant improvement in symptoms post-surgery.

Implications:

• This case highlights the importance of considering plexiform neurofibromas in the differential diagnosis of leg lesions, even when atypical.
• Early diagnosis and surgical intervention can lead to favorable outcomes for patients with NF1-associated tumors.
• Giant plexiform neurofibromas, though rare, require prompt management to alleviate patient suffering and improve quality of life.