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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

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[MIKAMINOM ANTIFUNGAL THERAPY IN NEWBORNS AND INFANTS WITH SURGICAL PATHOLOGY]

N I Melnikova, I A Strogonov, E V Kartseva

    Anesteziologiia I Reanimatologiia
    |May 20, 2016
    PubMed

    Insights

    Multidrug-resistant fungal infections are increasing in neonatal intensive care units (ICUs). Micafungin offers an alternative antifungal therapy for neonates and infants at risk, especially after abdominal surgery.

    Area of Science:

    • Neonatal intensive care
    • Infectious diseases
    • Pharmacology

    Background:

    • Prolonged antibiotic use in neonatal intensive care units (ICUs) contributes to the rise of drug-resistant fungal infections.
    • Neonates undergoing abdominal surgery face a high risk of developing fungal infections.

    Purpose of the Study:

    • To highlight the challenge of invasive fungal infections in neonates.
    • To introduce micafungin as a viable alternative antifungal agent.

    Main Methods:

    • Review of current therapeutic challenges in neonatal fungal infections.
    • Evaluation of micafungin as an alternative to fluconazole in neonates and infants.

    Main Results:

    • Micafungin is presented as an effective alternative for treating invasive fungal infections in neonates.
    • Dosage recommendations for micafungin (2-8 mg/kg/day) are provided based on clinical assessment.

    Conclusions:

    • Micafungin represents a crucial advancement in managing fungal infections in vulnerable neonatal populations.
    • Judicious use of antifungals like micafungin is essential in neonatal ICUs to combat rising resistance.

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