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Updated: Mar 21, 2026
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
Triglycerides are a predictive factor for arterial stiffness: a community-based 4.8-year prospective study
Xiaona Wang1, Ping Ye2, Ruihua Cao1
1Department of Geriatric Cardiology, Chinese PLA General Hospital, Fuxing Road #28, Beijing, 100853, China.
Insights
Higher triglyceride levels are linked to increased arterial stiffness, particularly in older adults. Lowering triglycerides may help reduce cardiovascular disease risk by improving arterial health.
Area of Science:
- Cardiology
- Vascular Biology
- Epidemiology
Background:
- Triglycerides (TGs) show an independent effect on coronary heart disease risk, even with controlled LDL cholesterol.
- Arterial stiffness is a key predictor of cardiovascular and atherosclerotic diseases.
- The link between triglycerides and arterial stiffness requires further characterization.
Purpose of the Study:
- To investigate the relationship between triglyceride levels and arterial stiffness.
- To analyze this association in a community-based longitudinal sample in Beijing, China.
Main Methods:
- Plasma triglyceride levels were measured and related to arterial stiffness parameters (carotid-femoral PWV and carotid-radial PWV).
- The study included 1447 participants with a mean age of 61.3 years.
- Data analysis involved multiple linear regression and multivariate logistic regression.
Main Results:
- Triglycerides were independently associated with both carotid-femoral PWV and carotid-radial PWV.
- This association was stronger in individuals older than 65 years.
- Increased triglycerides correlated with a higher likelihood of increased carotid-femoral PWV in older adults.
Conclusions:
- Lower triglyceride levels are significantly associated with reduced carotid-femoral PWV.
- Achieving low triglyceride levels may be a valuable therapeutic strategy for managing atherosclerotic disease.
Background:
Epidemiological studies have disclosed an independent effect of triglycerides on coronary heart disease despite achievement of low-density lipoprotein cholesterol goals with statin therapy. Arterial stiffness has been increasingly recognized as a strong predictor of cardiovascular disease and atherosclerotic disease. The association between triglycerides and arterial stiffness is not well characterized. We aimed to determine the relationship between triglycerides and arterial stiffness in a community-based longitudinal sample from Beijing, China.
Methods:
We related levels of plasma TGs to measures of arterial stiffness (carotid-femoral pulse wave velocity [PWV] and carotid-radial PWV) in 1447 subjects (mean age, 61.3 years) from a community-based population in Beijing, China.
Results:
After a median follow-up interval of 4.8 years, multiple linear regression analysis revealed that TGs were independently associated with carotid-femoral PWV (β = 0.747, P < 0.001) and carotid-radial PWV (β = 0.367, P = 0.001). In the group older than 65 years, the association between baseline TG levels and follow-up carotid-femoral PWV (β = 1.094, P = 0.001) and carotid-radial PWV (β = 0.524, P = 0.002) were strengthened. In forward stepwise multivariate logistic regression analysis, every SD increase in TGδ was associated with a 1.296-increased likelihood of the presence of carotid-femoral PWVδII (OR [per SD increase in TGδ]: 1.296; 95% CI: 1.064 ~ 1.580; P = 0.010) in Model 2, whereas the relationship between TGδ and carotid-radial PWVδII disappeared. In addition, the relationship was strengthened between TGδ and the presence of carotid-femoral PWVδII (OR 1.526, 95% CI: 1.088-2.141, P = 0.014) in the group older than 65 years but not carotid-radial PWVδII. No association was noted in subjects younger than 65 years.
Conclusions:
Lower triglyceride levels were significantly associated with decreases in carotid-femoral PWV, indicating that achieving low TG levels may be an additional therapeutic consideration in subjects with atherosclerotic disease.
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