Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.7K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.7K
Liver Regeneration01:24

Liver Regeneration

4.7K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.7K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.7K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventilator-associated pneumonia prevention: Past, present, perspective.

Journal of critical care·2026
Same author

Exploring carboxyhemoglobin as a predictive marker of hemolysis-related CSA-AKI.

Journal of clinical anesthesia·2026
Same author

Probabilistic MRI Maps for the Presentation and Management of Intracranial Meningiomas.

Radiology. Imaging cancer·2026
Same author

Postoperative Respiratory Support After Cardiac Surgery: The BREASE ARC International Survey.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Tolerability and efficacy profile of S-ketamine compared with racemic ketamine in surgical patients, a prospective observational before-and-after study in the perioperative setting.

BJA open·2026
Same author

From intraosseous meningioma and ossified metaplastic meningioma to osteomeningioma: a novel voxel-based, atlas-normalized MRI framework for the radiological classification of skull-involving meningiomas.

Neuroimage. Reports·2026

Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

1.7K

Muscle regeneration after sepsis.

Adrien Bouglé1,2, Pierre Rocheteau3, Tarek Sharshar3,4,5,6

  • 1Human Histopathology and Animal Models Unit, Infection and Epidemiology Department, Institut Pasteur, 75724 cedex15, Paris, France. adrien.bougle@aphp.fr.

Critical Care (London, England)
|May 20, 2016
PubMed
Summary

Intensive care unit-acquired weakness (ICU-AW) may stem from impaired muscle regeneration. Mesenchymal stem cell treatment shows promise for improving muscle recovery after critical illness.

More Related Videos

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

23.4K
Examining Muscle Regeneration in Zebrafish Models of Muscle Disease
07:58

Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Published on: January 18, 2021

5.8K

Related Experiment Videos

Last Updated: Mar 21, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

1.7K
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

23.4K
Examining Muscle Regeneration in Zebrafish Models of Muscle Disease
07:58

Examining Muscle Regeneration in Zebrafish Models of Muscle Disease

Published on: January 18, 2021

5.8K

Area of Science:

  • Critical care medicine
  • Muscle physiology
  • Regenerative medicine

Background:

  • Severe critical illness frequently leads to intensive care unit-acquired weakness (ICU-AW).
  • ICU-AW is linked to higher mortality, prolonged mechanical ventilation, and lasting functional impairments.
  • The role of muscle regeneration in ICU-AW pathophysiology remains under-explored despite functional evidence.

Purpose of the Study:

  • To investigate the role of muscle regeneration in the development of ICU-AW.
  • To explore the potential of mesenchymal stem cells in enhancing post-injury muscle recovery in the context of critical illness.

Main Methods:

  • Review of existing literature on ICU-AW pathophysiology.
  • Analysis of recent data on muscle regeneration after sepsis.
  • Evaluation of mesenchymal stem cell efficacy in preclinical models of muscle injury.

Main Results:

  • Muscle regeneration may be impaired following critical illness, particularly sepsis.
  • Mesenchymal stem cell treatment has demonstrated potential in improving muscle recovery post-injury.
  • Protracted functional consequences of ICU-AW suggest a role for regenerative processes.

Conclusions:

  • Impaired muscle regeneration is a potential contributing factor to ICU-AW.
  • Mesenchymal stem cell therapy warrants further investigation as a therapeutic strategy for ICU-AW.
  • Targeting muscle regeneration pathways could mitigate long-term disability in critical illness survivors.