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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
Superficial Mycoses Associated with Diaper Dermatitis
Alexandro Bonifaz1, Rubí Rojas2, Andrés Tirado-Sánchez3
1Department of Mycology and Dermatology Service, Hospital General de México, "Dr. Eduardo Liceaga", Dr. Balmis 148, Col Doctores, CP 06720, Mexico, DF, Mexico. a_bonifaz@yahoo.com.mx.
Abstract:
Diapers create particular conditions of moisture and friction, and with urine and feces come increased pH and irritating enzymes (lipases and proteases). Fungi can take advantage of all these factors. Candida yeasts, especially C. albicans, are responsible for the most frequent secondary infections and are isolated in more than 80 % of cases. Correct diagnosis is important for ensuring the correct prescription of topical antimycotics. Nystatin, imidazoles and ciclopirox are effective. It is important to realize there are resistant strains. Dermatophytes can infect the diaper area, with the most common agent being Epidermophyton floccosum. The clinical characteristics of dermatophytosis are different from those of candidiasis, and it can be diagnosed and treated simply. Malassezia yeasts can aggravate conditions affecting the diaper area, such as seborrheic dermatitis, atopic dermatitis, and inverse psoriasis. Additional treatment is recommended in this case, because they usually involve complement activation and increased specific IgE levels. Erythrasma is a pseudomycosis that is indistinguishable from candidiasis and may also occur in large skin folds. It is treated with topical antibacterial products and some antimycotics.
Insights
Diaper area infections are often caused by Candida yeasts, necessitating accurate diagnosis for effective topical antifungal treatment. Other fungi like dermatophytes and Malassezia, plus conditions like erythrasma, also require specific management strategies.
Area of Science:
- Dermatology
- Mycology
- Infectious Diseases
Background:
- Diaper environments promote fungal growth due to moisture, friction, and altered pH.
- Candida yeasts, particularly Candida albicans, are the most common cause of secondary infections in the diaper area, found in over 80% of cases.
- Other fungi like dermatophytes and Malassezia, as well as the bacterial pseudomycosis erythrasma, can also affect this region.
Purpose of the Study:
- To review the common fungal and pseudomycosis infections in the diaper area.
- To highlight the importance of accurate diagnosis for appropriate treatment selection.
- To discuss the specific characteristics and management of candidiasis, dermatophytosis, Malassezia-related conditions, and erythrasma.
Main Methods:
- Literature review of fungal and pseudomycosis infections in diaper areas.
- Analysis of etiological agents, clinical presentations, and treatment options.
- Emphasis on differential diagnosis between various conditions.
Main Results:
- Candida albicans is the predominant pathogen (>80%), requiring specific topical antimycotics like nystatin, imidazoles, or ciclopirox, with awareness of resistant strains.
- Dermatophytosis, caused by agents like Epidermophyton floccosum, presents differently and is easily diagnosed and treated.
- Malassezia yeasts can exacerbate existing skin conditions, and erythrasma is a bacterial pseudomycosis mimicking candidiasis.
Conclusions:
- Accurate diagnosis is crucial for effective treatment of diaper area infections.
- Topical antimycotics are effective for candidiasis, but resistance should be considered.
- Dermatophytosis, Malassezia exacerbations, and erythrasma require distinct diagnostic and therapeutic approaches.
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