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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
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Obesity, Inflammation, and Cancer
Tuo Deng1,2, Christopher J Lyon1, Stephen Bergin3,4
1Diabetes Research Center and Center for Bioenergetics, Houston Methodist Research Institute, Houston, Texas 77030;
Annual Review of Pathology
|May 20, 2016
Summary
Obesity drives cancer risk through chronic inflammation and hormonal changes from adipose tissue. Understanding these links is key to preventing obesity-related cancers.
Area of Science:
- Oncology
- Endocrinology
- Immunology
Background:
- Obesity is a global epidemic linked to increased cancer incidence and mortality.
- Chronic inflammation, a hallmark of obesity, significantly mediates cancer development.
- Adipose tissue dysfunction in obesity exacerbates inflammation and cancer risk.
Purpose of the Study:
- To elucidate the mechanisms linking obesity-induced adipose tissue inflammation to cancer.
- To review how obesity-associated metabolic dysregulation impacts tumor growth.
- To discuss the role of these mechanisms in specific obesity-associated cancers.
Main Methods:
- Review of current literature on obesity, inflammation, and cancer.
- Analysis of the endocrine functions of adipose tissue in obesity.
- Examination of metabolic alterations in obesity and their protumoral effects.
Main Results:
- Obesity leads to adipose tissue inflammation, increasing systemic proinflammatory factors.
- Adipose-derived cells and hormones (leptin, adiponectin) influence the tumor microenvironment.
- Metabolic dysregulation (insulin resistance, dyslipidemia) promotes tumor development.
Conclusions:
- Obesity-induced inflammation and metabolic changes are critical drivers of cancer.
- Adipose tissue plays a direct role in promoting cancer through cellular and hormonal signaling.
- Targeting obesity-related inflammation and metabolic pathways may offer novel cancer prevention and treatment strategies.
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