Current situation and future usage of anticancer drug databases

Area of Science:

• Oncology
• Bioinformatics
• Drug Discovery

Background:

• Cancer poses a significant global health challenge with rising incidence and mortality.
• Targeted cancer therapy has rapidly advanced in the last 15 years, identifying numerous drugs, targets, and mutations.
• Databases are crucial for organizing and accessing information on anticancer drugs and their mechanisms.

Purpose of the Study:

• To provide a comprehensive overview of existing anticancer drug databases.
• To analyze the strengths and weaknesses of these databases.
• To discuss the future utility of these databases in facilitating new drug discovery.

Main Methods:

• Systematic review of literature on anticancer drug databases.
• Analysis of database content, including drug-target interactions, resistance/sensitivity data, and drug-drug interactions.
• Evaluation of databases focusing on specific anticancer agents like natural products, peptides, and inhibitors.

Main Results:

• Numerous databases exist, offering integrated information on anticancer drugs and their associated data.
• Databases cover diverse aspects such as drug-target interactions, genetic mutations, and natural product-derived anticancer agents.
• Key information includes drug resistance/sensitivity, drug-drug interactions, and specific inhibitor classes.

Conclusions:

• Anticancer drug databases are invaluable tools for researchers and clinicians.
• These databases support the identification of novel therapeutic targets and drug candidates.
• Optimizing the use and development of these databases can lead to improved cancer treatment outcomes.