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Related Experiment Video

Updated: Mar 21, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

Published on: August 23, 2007

Imaging Immunity in Lymph Nodes: Past, Present and Future.

James Butler^1,2,3, Amy Sawtell¹, Simon Jarrett^1,2,3

¹Centre for Immunology and Infection, Department of Biology, York, YO10 5DD, UK.

Advances in Experimental Medicine and Biology

|May 20, 2016

Summary

Biophysics advances enable precise quantification of immune cell migration and interactions. This provides new mechanistic understanding of immune responses, crucial for developing next-generation immunotherapies and vaccines.

Keywords:

Cellular interactions Imaging Immunity Lymph nodes Migration Modelling Multi-photon

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Last Updated: Mar 21, 2026

Dissection and 2-Photon Imaging of Peripheral Lymph Nodes in Mice

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Published on: August 23, 2007

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy

Published on: August 9, 2019

Intravital Imaging of the Mouse Popliteal Lymph Node

Intravital Imaging of the Mouse Popliteal Lymph Node

Published on: February 8, 2012

Area of Science:

Immunology
Biophysics
Cellular Biology

Background:

Immune responses rely on complex cell interactions, but mechanisms of immune cell trafficking and function were unclear.
Quantifying immune cell migration historically used radiolabeling, lacking detailed mechanistic insight.

Observation:

Advances in multi-photon microscopy, probes, and animal models allow 3D visualization of cellular behaviors in lymphoid tissues over time.
Deep tissue imaging techniques enhance resolution, speed, sensitivity, and data analysis for single-cell immune response quantification.

Findings:

Multi-photon microscopy reveals insights into immune homeostasis, pathogen response, anti-tumor immunity, and autoimmune diseases by quantifying cellular migration and interactions.
Quantitative data from advanced imaging facilitates the development of high-fidelity mathematical and computational models of immune function.

Implications:

Biophysical approaches revolutionize understanding of immune function, impacting the development of novel immunotherapies and vaccines.
This quantitative framework supports simulation-guided experimentation and the design of next-generation immunotherapeutics.