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Alterations in bovine lymphocyte function during the periparturient period
M E Kehrli1, B J Nonnecke, J A Roth
1USDA, National Animal Disease Center, Ames, IA 50010.
American Journal of Veterinary Research
|February 1, 1989
Summary
Periparturient Holstein heifers showed increased lymphocyte blastogenesis before calving but marked impairment after calving. This immune response change is crucial for understanding postpartum health in dairy cattle.
Area of Science:
- Immunology
- Veterinary Medicine
- Dairy Science
Background:
- The periparturient period is a critical transition for dairy cows, often associated with immunosuppression.
- Understanding immune cell function during this period is vital for preventing diseases in postpartum dairy cattle.
Purpose of the Study:
- To evaluate mitogen-induced lymphocyte blastogenic responses in Holstein heifers during the periparturient period.
- To assess changes in immune cell function in relation to calving.
Main Methods:
- Blood samples were collected from 8 Holstein heifers.
- Lymphocyte blastogenic responses were measured using phytohemagglutinin P (PHA) and concanavalin A (ConA) as mitogens.
Main Results:
- Lymphocyte blastogenesis induced by PHA increased 2 weeks before parturition.
- Concanavalin A-induced lymphocyte blastogenesis increased 3 weeks before parturition.
- A marked impairment of lymphocyte blastogenesis was observed by the first week after parturition.
Conclusions:
- Holstein heifers exhibit altered lymphocyte function around the time of calving.
- Immune responses are temporarily enhanced prepartum but significantly suppressed postpartum, highlighting a window of vulnerability.