Vein graft failure: from pathophysiology to clinical outcomes

Related Experiment Video

Updated: Mar 21, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
09:04

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

9.3K

Margreet R de Vries1,2, Karin H Simons1,2, J Wouter Jukema2,3

  • 1Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands.

Nature Reviews. Cardiology
|May 20, 2016
PubMed

Insights

Vein graft failure is a major issue in bypass surgery for arterial disease. This review explores causes and new treatments to improve graft patency and patient outcomes.

Area of Science:

  • Vascular Surgery
  • Cardiology
  • Regenerative Medicine

Background:

  • Occlusive arterial disease significantly impacts global morbidity and mortality.
  • Bypass graft surgery, using great saphenous veins, is a primary revascularization method but suffers high failure rates.
  • Maintaining vein graft patency is critical for successful long-term surgical outcomes.

Purpose of the Study:

  • To review preclinical and clinical studies on the pathophysiology of vein graft failure.
  • To explore the latest therapeutic strategies aimed at enhancing vein graft patency for both coronary and peripheral applications.

Main Methods:

  • Comprehensive literature review of preclinical and clinical studies.
  • Analysis of pathophysiological mechanisms contributing to vein graft failure.
  • Evaluation of current and emerging therapeutic interventions for graft patency.

Main Results:

  • Great saphenous vein grafts have a high failure rate, impacting surgical success.
  • Limited interventions, excluding 'no-touch' techniques and specific medical therapies, have proven effective in preventing graft failure.
  • Ongoing research focuses on understanding vein graft failure mechanisms and developing novel solutions.

Conclusions:

  • Vein graft failure remains a significant challenge in treating occlusive arterial disease.
  • Further research into pathophysiology and therapeutic options is essential to improve long-term vein graft patency.
  • Novel strategies are needed to enhance the durability of bypass grafts in cardiovascular and peripheral interventions.

More Related Videos

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency07:22

Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency

Published on: January 15, 2017

9.3K
A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure07:02

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Published on: May 15, 2020

6.4K

Related Concept Videos

Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
311
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
655
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
551
Venous Return01:04

Venous Return

The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
13.4K
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
281
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
422