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Updated: Mar 21, 2026

Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
Site of Mammalian Sperm Acrosome Reaction
1Oki Marine Biological Station, Education and Research Center for Biological Resources, Shimane University, 194 Kamo, Okinoshima-cho, Oki, Shimane, 685-0024, Japan. hiro@life.shimane-u.ac.jp.
Abstract:
Until recently, no special attention has been paid to the question of the site of mammalian sperm acrosome reaction (AR) in the female reproductive tract. Because AR is an essential process that enables the spermatozoon to fertilize, it is generally believed that it occurs at a specific step during sperm-egg interaction. It is generally thought that "the site of action coincides with the site of commitment." Thus, understanding the roles of AR and acrosomal substances is needed to gain insight into the site of the sperm commitment to undergo AR.
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