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Updated: Mar 21, 2026
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
Published on: July 14, 2023
Long-term outcomes of simultaneous guided bone regeneration using native and cross-linked collagen membranes after
Frank Schwarz1, Andrea Schmucker1, Jürgen Becker1
1Department of Oral Surgery, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
Objectives:
To assess the clinical outcomes of simultaneous guided bone regeneration using native (CM) and cross-linked (VN) collagen membranes at 8 years.
Materials And Methods:
A total of n = 19 patients (19 implants) were available for the analysis. Each subject had received a simultaneous grafting of dehiscence-type defects using a natural bone mineral (NBM) and a random allocation to either CM and VN membranes (submerged healing of 4 months). Clinical parameters (e.g., bleeding on probing - BOP, probing pocket depth - PD, mucosal recession - MR, clinical attachment level - CAL) were recorded at 8 years after prosthesis installation.
Results:
At 8 years, CM and VN groups revealed comparable median BOP, PD, MR and CAL values at both vestibular and oral aspects. From 4 to 8 years (n = 14 patients), median CAL at the vestibular aspect improved in both groups; however, these changes were significantly higher at CM-treated sites (CM: 0.7 mm vs. VN: 0.5 mm).
Conclusion:
The clinical long-term outcomes at 8 years were comparable in both VN and CM groups.
