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Updated: Mar 21, 2026
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Published on: September 27, 2019
Transfer of Two-Dimensional Oligonucleotide Patterns onto Stereocontrolled Plasmonic Nanostructures through
Yinan Zhang1,2, Jie Chao1, Huajie Liu3
1Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications Institution, 9 Wenyuan Road, Nanjing, 210046, China.
Abstract:
The precise functionalization of self-assembled nanostructures with spatial and stereocontrol is a major objective of nanotechnology and holds great promise for many applications. Herein, the nanoscale addressability of DNA origami was exploited to develop a precise copy-machine-like platform that can transfer two-dimensional oligonucleotide patterns onto the surface of gold nanoparticles (AuNPs) through a deliberately designed toehold-initiated DNA displacement reaction. This strategy of DNA-origami-based nanoimprinting lithography (DONIL) demonstrates high precision in controlling the valence and valence angles of AuNPs. These DNA-decorated AuNPs act as precursors in the construction of discrete AuNP clusters with desired chirality.
