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Acute side effects of three commonly used gadolinium contrast agents in the paediatric population

Chris Neeley1, Michael Moritz1, Jeffrey J Brown1

  • 1Department of Radiology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.

The British Journal of Radiology
|May 20, 2016
PubMed

Insights

Gadolinium contrast agents like MultiHance, Magnevist, and Gadavist show low acute side effects in children. Sedation further reduces risks, though MultiHance had more GI symptoms without it.

Area of Science:

  • Radiology
  • Pediatric Imaging
  • Pharmacovigilance

Background:

  • Gadolinium-based contrast agents (GBCAs) are essential for pediatric imaging.
  • Understanding the safety profile of different GBCAs in children is crucial for clinical practice.

Purpose of the Study:

  • To evaluate and compare the incidence of acute side effects associated with three common GBCAs (MultiHance, Magnevist, Gadavist) in pediatric patients.

Main Methods:

  • A retrospective review of medical records was conducted.
  • The study analyzed acute adverse events in pediatric patients who received intravenous MultiHance, Magnevist, or Gadavist.

Main Results:

  • Overall incidence of acute side effects was 1.7% (40/2393 patients).
  • Nausea and vomiting were the most common side effects.
  • Incidence was higher in non-sedated patients (2.37% vs. 0.7%).
  • MultiHance showed a higher incidence of nausea and vomiting compared to Magnevist and Gadavist in non-sedated children.

Conclusions:

  • MultiHance, Magnevist, and Gadavist exhibit a low incidence of acute side effects in the pediatric population.
  • Sedation is associated with a reduced rate of adverse events.
  • MultiHance was linked to a higher incidence of gastrointestinal symptoms compared to Magnevist and Gadavist.
Abstract

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