Four Different Tumors Arising in a Nevus Sebaceous

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Nevus sebaceous is a congenital skin anomaly often associated with secondary tumors.
• Multiple secondary tumors arising from a single nevus sebaceous are exceptionally rare.

Observation:

• A 67-year-old female presented with a nevus sebaceous on her scalp exhibiting a plaque with a nodule and an erosive lesion.
• Histopathological examination revealed diverse neoplastic components within the lesions.

Findings:

• The black node showed atypical basaloid cells, suggestive of basal cell carcinoma.
• The erosive lesion contained apocrine epithelium (syringocystadenoma papilliferum).
• The plaque demonstrated enlarged sebaceous lobules (sebaceoma) and follicular germ structures (trichoblastoma).

Implications:

• This case represents an extremely rare occurrence of four distinct tumors arising from a single nevus sebaceous.
• It underscores the importance of thorough histopathological evaluation of nevus sebaceous lesions.
• Understanding these rare associations aids in diagnosis and patient management.